Publications

La PGTB est associée chaque année dans de nombreuses publications, en co-autorat ou en remerciement.

La PGTB doit être a minima mentionnée dans les remerciements des publications issues des projets réalisés à la plateforme. La phrase suivante est proposée :

« Part of the experiments (specify which ones) were performed at the PGTB (doi:10.15454/1.5572396583599417E12) with the help of (specify with whom) ».

L’affiliation suivante doit être systématiquement utilisée :

Univ. Bordeaux, INRAE, BIOGECO, F-33610 Cestas, France

2022

Mishra, B., Ulaszewski, B., Meger, J., Aury, J.-M., Bodénès, C., Lesur-Kupin, I., Pfenninger, M., Da Silva, C., Gupta, D.K., Guichoux, E., Heer, K., Lalanne, C., Labadie, K., Opgenoorth, L., Ploch, S., Le Provost, G., Salse, J., Scotti, I., Wötzel, S., Plomion, C., Burczyk, J., Thines, M., 2022. A Chromosome-Level Genome Assembly of the European Beech (Fagus sylvatica) Reveals Anomalies for Organelle DNA Integration, Repeat Content and Distribution of SNPs. Frontiers in Genetics 12. https://doi.org/10.3389/fgene.2021.691058

Ravigné, V., Becker, N., Massol, F., Guichoux, E., Boury, C., Mahé, F., Facon, B., n.d. Fruit fly phylogeny imprints bacterial gut microbiota. Evolutionary Applications n/a. https://doi.org/10.1111/eva.13352

2021

Aguayo J, Husson C, Chancerel E, Fabreguettes O, Chandelier A, Fourrier-Jeandel C, et al. Combining permanent aerobiological networks and molecular analyses for large-scale surveillance of forest fungal pathogens: A proof-of-concept. Plant Pathology. 2021;70(1):181‑94.https://doi.org/10.1111/ppa.13265

Blanc-Jolivet C, Mader M, Bouda H-N, Massot M, Daïnou K, Yene G, et al. Development of new SNP and INDEL loci for the valuable African timber species Lophira alata. Conservation Genet Resour. mars 2021;13(1):85‑7. https://doi.org/10.1007/s12686-020-01173-5

Dubart M, Alonso P, Barroso-Bergada D, Becker N, Bethune K, Bohan DA, et al. Chapter Nine – Coupling ecological network analysis with high-throughput sequencing-based surveys: Lessons from the next-generation biomonitoring project. In: Bohan DA, Dumbrell AJ, Vanbergen AJ, éditeurs. Advances in Ecological Research [Internet]. Academic Press; 2021 [cité 4 mars 2022]. p. 367‑430. (The Future of Agricultural Landscapes, Part III; vol. 65). https://doi.org/10.1016/bs.aecr.2021.10.007

Enaud R, Cambos S, Viaud E, Guichoux E, Chancerel E, Marighetto A, et al. Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study. Nutrients. 13 nov 2021;13(11):4061. https://doi.org/10.3390/nu13114061

Gross A, Petitcollin C, Dutech C, Ly B, Massot M, Faivre d’Arcier J, et al. Hidden invasion and niche contraction revealed by herbaria specimens in the fungal complex causing oak powdery mildew in Europe. Biological Invasions. 2021;1‑17. https://doi.org/10.1007/s10530-020-02409-z

Larue C, Guichoux E, Laurent B, Barreneche T, Robin C, Massot M, et al. Development of highly validated SNP markers for genetic analyses of chestnut species. Conservation Genetics Resources. 2021;13:383‑8. https://doi.org/10.1007/s12686-021-01220-9

Leal BSS, Chaves CJN, Graciano VA, Boury C, Huacre LAP, Heuertz M, et al. Evidence of local adaptation despite strong drift in a Neotropical patchily distributed bromeliad. Heredity (Edinb). août 2021;127(2):203‑18. https://doi.org/10.1038/s41437-021-00442-9

Padrón M, Milhes M, Delcamp A, Guichoux E. Identification of SNP markers for population genetics studies of the Mediterranean gorgonian, Leptogorgia sarmentosa. Conservation Genetics Resources. 5 juill 2021;1. https://doi.org/10.1007/s12686-021-01218-3

Postolache D, Oddou-Muratorio S, Vajana E, Bagnoli F, Guichoux E, Hampe A, et al. Genetic signatures of divergent selection in European beech (Fagus sylvatica L.) are associated with the variation in temperature and precipitation across its distribution range. Molecular Ecology. 2021;30(20):5029‑47. https://doi.org/10.1111/mec.16115

2020

Alexandre, H., Truffaut, L., Klein, E., Ducousso, A., Chancerel, E., Lesur, I., Dencausse, B., Louvet, J.-M., Nepveu, G., Torres‐Ruiz, J.M., Lagane, F., Musch, B., Delzon, S., Kremer, A., 2020. How does contemporary selection shape oak phenotypes? Evolutionary Applications 13, 2772–2790. https://doi.org/10/ghvkff

Blanc-Jolivet, C., Bakhtina, S., Yanbaev, R., Yanbaev, Y., Mader, M., Guichoux, E., Degen, B., 2020a. Development of new SNPs loci on Quercus robur and Quercus petraea for genetic studies covering the whole species’ distribution range. Conservation Genet Resour 12, 597–600. https://doi.org/10/ghvkfp

Blanc-Jolivet, C., Mader, M., Bouda, H.-N., Massot, M., Daïnou, K., Yene, G., Opuni-Frimpong, E., Degen, B., 2020b. Development of new SNP and INDEL loci for the valuable African timber species Lophira alata. Conservation Genet Resour. https://doi.org/10/ghvkfj

Dutech, C., Feau, N., Lesur, I., Ehrenmann, F., Letellier, T., Li, B., Mouden, C., Guichoux, E., Desprez-Loustau, M.L., Gross, A., 2020. An easy and robust method for isolation and validation of single-nucleotide polymorphic markers from a first Erysiphe alphitoides draft genome. Mycol Progress 19, 615–628. https://doi.org/10/ghxd2c

Honorio Coronado, E.N., Blanc-Jolivet, C., Mader, M., García-Dávila, C.R., Aldana Gomero, D., del Castillo Torres, D., Flores Llampazo, G., Hidalgo Pizango, G., Sebbenn, A.M., Meyer-Sand, B.R.V., Paredes-Villanueva, K., Tysklind, N., Troispoux, V., Massot, M., Carvalho, C., de Lima, H.C., Cardoso, D., Degen, B., 2020. SNP Markers as a Successful Molecular Tool for Assessing Species Identity and Geographic Origin of Trees in the Economically Important South American Legume Genus Dipteryx. Journal of Heredity 111, 346–356. https://doi.org/10/ghvkfw

Lapègue, S., Heurtebise, S., Cornette, F., Guichoux, E., Gagnaire, P.-A., 2020. Genetic Characterization of Cupped Oyster Resources in Europe Using Informative Single Nucleotide Polymorphism (SNP) Panels. Genes 11, 451. https://doi.org/10/ghxd3k

Laurent, B., Larue, C., Chancerel, E., Guichoux, E., Petit, R.J., Barreneche, T., Robin, C., Lepais, O., 2020a. Microhaplotype genotyping-by-sequencing of 98 highly polymorphic markers in three chestnut tree species. Conservation Genet Resour 12, 567–580. https://doi.org/10/ghxd3m

Laurent, B., Marchand, M., Chancerel, E., Saint-Jean, G., Capdevielle, X., Poeydebat, C., Bellée, A., Comont, G., Villate, L., Desprez-Loustau, M.-L., 2020b. A Richer Community of Botryosphaeriaceae Within a Less Diverse Community of Fungal Endophytes in Grapevines than in Adjacent Forest Trees Revealed by a Mixed Metabarcoding Strategy. Phytobiomes Journal 4, 252–267. https://doi.org/10/ghxd3n

Lepais, O., Chancerel, E., Boury, C., Salin, F., Manicki, A., Taillebois, L., Dutech, C., Aissi, A., Bacles, C.F.E., Daverat, F., Launey, S., Guichoux, E., 2020. Fast sequence-based microsatellite genotyping development workflow. PeerJ 8. https://doi.org/10/ghxd3p

Padrón, M., Milhes, M., Massot, M., Guichoux, E., 2020. Development of a set of SNP markers for population genetics of the red gorgonian (Paramuricea clavata), an emblematic species of the Mediterranean coralligenous. Conservation Genet Resour 12, 521–523. https://doi.org/10/ghxd3q

Pakull, B., Schindler, L., Mader, M., Kersten, B., Blanc-Jolivet, C., Paulini, M., Lemes, M.R., Ward, S.E., Navarro, C.M., Cavers, S., Sebbenn, A.M., di Dio, O., Guichoux, E., Degen, B., 2020. Development of nuclear SNP markers for Mahogany (Swietenia spp.). Conservation Genet Resour 12, 585–587. https://doi.org/10/ghxd3r

Pauvert, C., Fort, T., Calonnec, A., d’Arcier, J.F., Chancerel, E., Massot, M., Chiquet, J., Robin, S., Bohan, D.A., Vallance, J., Vacher, C., 2020. Microbial association networks give relevant insights into plant pathobiomes. bioRxiv 2020.02.21.958033. https://doi.org/10/ggp3zm

Villellas, J., Martín-Forés, I., Mariette, S., Massot, M., Guichoux, E., Acuña-Míguez, B., Hampe, A., Valladares, F., 2020. Functional distance is driven more strongly by environmental factors than by genetic relatedness in Juniperus thurifera L. expanding forest stands. Annals of Forest Science 77, 66. https://doi.org/10/ghxd26

2019

Blanc-Jolivet, C., Mader, M., Bouda, H.-N., Guichoux, E., Yene, G., Opuni-Frimpong, E., Degen, B., 2019. Development of SNP markers for the African timber species Nauclea diderrichii. Conservation Genet Resour. https://doi.org/10.1007/s12686-019-01115-w

Bouteiller, X.P., Verdu, C.F., Aikio, E., Bloese, P., Dainou, K., Delcamp, A., Thier, O.D., Guichoux, E., Mengal, C., Monty, A., Pucheu, M., Loo, M. van, Porté, A.J., Lassois, L., Mariette, S., 2019. A few north Appalachian populations are the source of European black locust. Ecology and Evolution 9, 2398–2414. https://doi.org/10.1002/ece3.4776

Enaud, R., Hooks, K.B., Barre, A., Barnetche, T., Hubert, C., Massot, M., Bazin, T., Clouzeau, H., Bui, S., Fayon, M., Berger, P., Lehours, P., Bébéar, C., Nikolski, M., Lamireau, T., Delhaes, L., Schaeverbeke, T., 2019. Intestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn’s-Like Microbiota Disturbances. Journal of Clinical Medicine 8, 645. https://doi.org/10.3390/jcm8050645

Hipp, A.L., Whittemore, A.T., Garner, M., Hahn, M., Fitzek, E., Guichoux, E., Cavender-Bares, J., Gugger, P.F., Manos, P.S., Pearse, I.S., Cannon, C.H., 2019. Genomic Identity of White Oak Species in an Eastern North American Syngameon. Annals of the Missouri Botanical Garden 104, 455–477. https://doi.org/10.3417/2019434

Honorio Coronado, E.N., Blanc-Jolivet, C., Mader, M., García-Dávila, C.R., Sebbenn, A.M., Meyer-Sand, B.R.V., Paredes-Villanueva, K., Tysklind, N., Troispoux, V., Massot, M., Degen, B., 2019. Development of nuclear and plastid SNP markers for genetic studies of Dipteryx tree species in Amazonia. Conservation Genet Resour 11, 333–336. https://doi.org/10.1007/s12686-019-01081-3

Khattabi, L.A.E., Brun, S., Gueguen, P., Chatron, N., Guichoux, E., Schutz, S., Nectoux, J., Sorlin, A., Quere, M., Boudjarane, J., Tsatsaris, V., Mandelbrot, L., Schluth‐Bolard, C., Dupont, J.M., Rooryck, C., 2019. Performance of semiconductor sequencing platform for non-invasive prenatal genetic screening for fetal aneuploidy: results from a multicenter prospective cohort study in a clinical setting. Ultrasound in Obstetrics & Gynecology 54, 246–254. https://doi.org/10.1002/uog.20112

Pakull, B., Ekué, M.R.M., Bouka Dipelet, U.G., Doumenge, C., McKey, D.B., Loumeto, J.J., Opuni-Frimpong, E., Yorou, S.N., Nacoulma, B.M.Y., Guelly, K.A., Ramamonjisoa, L., Thomas, D., Guichoux, E., Loo, J., Degen, B., 2019. Genetic diversity and differentiation among the species of African mahogany (Khaya spp.) based on a large SNP array. Conserv Genet 20, 1035–1044. https://doi.org/10.1007/s10592-019-01191-3

Roques, S., Chancerel, E., Boury, C., Pierre, M., Acolas, M.-L., 2019. From microsatellites to single nucleotide polymorphisms for the genetic monitoring of a critically endangered sturgeon. Ecology and Evolution 9, 7017–7029. https://doi.org/10.1002/ece3.5268

Sebbenn, A.M., Blanc-Jolivet, C., Mader, M., Meyer-Sand, B.R.V., Paredes-Villanueva, K., Honorio Coronado, E.N., García-Dávila, C., Tysklind, N., Troispoux, V., Delcamp, A., Degen, B., 2019. Nuclear and plastidial SNP and INDEL markers for genetic tracking studies of Jacaranda copaia. Conservation Genet Resour 11, 341–343. https://doi.org/10.1007/s12686-019-01097-9

Tysklind, N., Blanc-Jolivet, C., Mader, M., Meyer-Sand, B.R.V., Paredes-Villanueva, K., Honorio Coronado, E.N., García-Dávila, C.R., Sebbenn, A.M., Caron, H., Troispoux, V., Guichoux, E., Degen, B., 2019. Development of nuclear and plastid SNP and INDEL markers for population genetic studies and timber traceability of Carapa species. Conservation Genet Resour 11, 337–339. https://doi.org/10.1007/s12686-019-01090-2

2018

Albertin, W., Chernova, M., Durrens, P., Guichoux, E., Sherman, D.J., Masneuf-Pomarede, I., Marullo, P., 2018. Many interspecific chromosomal introgressions are highly prevalent in Holarctic Saccharomyces uvarum strains found in human-related fermentations: Wine/cider S. uvarum strains show specific S. eubayanus introgressions. Yeast 35, 141–156. https://doi.org/10.1002/yea.3248

Avramova, M., Cibrario, A., Peltier, E., Coton, M., Coton, E., Schacherer, J., Spano, G., Capozzi, V., Blaiotta, G., Salin, F., Dols-Lafargue, M., Grbin, P., Curtin, C., Albertin, W., Masneuf-Pomarede, I., 2018. Brettanomyces bruxellensis population survey reveals a diploid-triploid complex structured according to substrate of isolation and geographical distribution. Scientific Reports 8. https://doi.org/10.1038/s41598-018-22580-7

Blanc-Jolivet, C., Kersten, B., Bourland, N., Guichoux, E., Delcamp, A., Doucet, J.-L., Degen, B., 2018. Development of nuclear SNP markers for the timber tracking of the African tree species Sapelli, Entandrophragma cylindricum. Conservation Genet Resour 10, 539–541. https://doi.org/10.1007/s12686-017-0872-4

Chandelier, A., Massot, M., Fabreguettes, O., Gischer, F., Teng, F., Robin, C., 2018. Early detection of Cryphonectria parasitica by real-time PCR. European Journal of Plant Pathology. https://doi.org/10.1007/s10658-018-1538-0

Delord, C., Lassalle, G., Oger, A., Barloy, D., Coutellec, M.-A., Delcamp, A., Evanno, G., Genthon, C., Guichoux, E., Bail, P.-Y.L., Quilliec, P.L., Longin, G., Lorvelec, O., Massot, M., Reveillac, E., Rinaldo, R., Roussel, J.-M., Vigouroux, R., Launey, S., Petit, E.J., 2018. A cost-and-time effective procedure to develop SNP markers for multiple species: A support for community genetics. Methods in Ecology and Evolution 0. https://doi.org/10.1111/2041-210X.13034

Desprez-Loustau, M.-L., Massot, M., Toïgo, M., Fort, T., Aday Kaya, A.G., Boberg, J., Braun, U., Capdevielle, X., Cech, T., Chandelier, A., Christova, P., Corcobado, T., Dogmus, T., Dutech, C., Fabreguettes, O., Faivre d’Arcier, J., Gross, A., Horta Jung, M., Iturritxa, E., Jung, T., Junker, C., Kiss, L., Kostov, K., Lehtijarvi, A., Lyubenova, A., Marçais, B., Oliva, J., Oskay, F., Pastirčák, M., Pastirčáková, K., Piou, D., Saint-Jean, G., Sallafranque, A., Slavov, S., Stenlid, J., Talgø, V., Takamatsu, S., Tack, A.J., 2018. From leaf to continent: The multi-scale distribution of an invasive cryptic pathogen complex on oak. Fungal Ecology 36, 39–50. https://doi.org/10.1016/j.funeco.2018.08.001

Dumas, P.-Y., Mansier, O., Prouzet-Mauleon, V., Koya, J., Villacreces, A., Brunet de la Grange, P., Luque Paz, D., Bidet, A., Pasquet, J.-M., Praloran, V., Salin, F., Kurokawa, M., Mahon, F.-X., Cardinaud, B., Lippert, E., 2018. MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative neoplasms. BMC Cancer 18, 1098. https://doi.org/10.1186/s12885-018-4993-2

Fitzek, E., Delcamp, A., Guichoux, E., Hahn, M., Lobdell, M., Hipp, A.L., 2018. A nuclear DNA barcode for eastern North American oaks and application to a study of hybridization in an Arboretum setting. Ecology and Evolution 8, 5837–5851. https://doi.org/10.1002/ece3.4122

García, C., Guichoux, E., Hampe, A., 2018. A comparative analysis between SNPs and SSRs to investigate genetic variation in a juniper species (Juniperus phoenicea ssp. turbinata). Tree Genetics & Genomes 14, 87. https://doi.org/10.1007/s11295-018-1301-x

Lesur, I., Alexandre, H., Boury, C., Chancerel, E., Plomion, C., Kremer, A., 2018. Development of Target Sequence Capture and Estimation of Genomic Relatedness in a Mixed Oak Stand. Frontiers in Plant Sciences 9, 996. https://doi.org/10.3389/fpls.2018.00996

Plomion, C., Aury, J.-M., Amselem, J., Leroy, T., Murat, F., Duplessis, S., Faye, S., Francillonne, N., Labadie, K., Le Provost, G., Lesur, I., Bartholomé, J., Faivre-Rampant, P., Kohler, A., Leplé, J.-C., Chantret, N., Chen, J., Diévart, A., Alaeitabar, T., Barbe, V., Belser, C., Bergès, H., Bodénès, C., Bogeat-Triboulot, M.-B., Bouffaud, M.-L., Brachi, B., Chancerel, E., Cohen, D., Couloux, A., Da Silva, C., Dossat, C., Ehrenmann, F., Gaspin, C., Grima-Pettenati, J., Guichoux, E., Hecker, A., Herrmann, S., Hugueney, P., Hummel, I., Klopp, C., Lalanne, C., Lascoux, M., Lasserre, E., Lemainque, A., Desprez-Loustau, M.-L., Luyten, I., Madoui, M.-A., Mangenot, S., Marchal, C., Maumus, F., Mercier, J., Michotey, C., Panaud, O., Picault, N., Rouhier, N., Rué, O., Rustenholz, C., Salin, F., Soler, M., Tarkka, M., Velt, A., Zanne, A.E., Martin, F., Wincker, P., Quesneville, H., Kremer, A., Salse, J., 2018. Oak genome reveals facets of long lifespan. Nature Plants. https://doi.org/10.1038/s41477-018-0172-3

Rosa, A.L., Miot-Sertier, C., Laizet, Y., Salin, F., Sipiczki, M., Bely, M., Masneuf-Pomarede, I., Albertin, W., 2018. Draft Genome Sequence of the Starmerella bacillaris (syn., Candida zemplinina) Type Strain CBS 9494. Microbiol Resour Announc 7, e00872-18. https://doi.org/10.1128/MRA.00872-18

Staedel, C., Tran, T.P.A., Giraud, J., Darfeuille, F., Di Giorgio, A., Tourasse, N.J., Salin, F., Uriac, P., Duca, M., 2018. Modulation of oncogenic miRNA biogenesis using functionalized polyamines. Scientific Reports 8, 1667. https://doi.org/10.1038/s41598-018-20053-5

Wagner, S., Lagane, F., Seguin-Orlando, A., Schubert, M., Leroy, T., Guichoux, E., Chancerel, E., Bech-Hebelstrup, I., Bernard, V., Billard, C., Billaud, Y., Bolliger, M., Croutsch, C., Čufar, K., Eynaud, F., Heussner, K.U., Köninger, J., Langenegger, F., Leroy, F., Lima, C., Martinelli, N., Momber, G., Billamboz, A., Nelle, O., Palomo, A., Piqué, R., Ramstein, M., Schweichel, R., Stäuble, H., Tegel, W., Terradas, X., Verdin, F., Plomion, C., Kremer, A., Orlando, L., 2018. High-Throughput DNA sequencing of ancient wood. Molecular Ecology 27, 1138–1154. https://doi.org/10.1111/mec.14514

Zarrillo, S., Gaikwad, N., Lanaud, C., Powis, T., Viot, C., Lesur, I., Fouet, O., Argout, X., Guichoux, E., Salin, F., Solorzano, R.L., Bouchez, O., Vignes, H., Severts, P., Hurtado, J., Yepez, A., Grivetti, L., Blake, M., Valdez, F., 2018. The use and domestication of Theobroma cacao during the mid-Holocene in the upper Amazon. Nature Ecology & Evolution 2, 1879. https://doi.org/10.1038/s41559-018-0697-x

2017

Blanc-Jolivet, C., Kersten, B., Bourland, N., Guichoux, E., Delcamp, A., Doucet, J.-L., Degen, B., 2017a. Development of nuclear SNP markers for the timber tracking of the African tree species Sapelli, Entandrophragma cylindricum. Conservation Genetics Resources 1–3. https://doi.org/10.1007/s12686-017-0872-4

Blanc-Jolivet, C., Kersten, B., Daïnou, K., Hardy, O., Guichoux, E., Delcamp, A., Degen, B., 2017b. Development of nuclear SNP markers for genetic tracking of Iroko, Milicia excelsa and Milicia regia. Conservation Genetics Resources 9, 531–533. https://doi.org/10.1007/s12686-017-0716-2

Desprez-Loustau, M.-L., Massot, M., Feau, N., Fort, T., de Vicente, A., Torés, J.A., Ortuño, D.F., 2017. Further Support of Conspecificity of Oak and Mango Powdery Mildew and First Report of Erysiphe quercicola and Erysiphe alphitoides on Mango in Mainland Europe. Plant Disease PDIS–01. https://doi.org/10.1094/PDIS-01-17-0116-RE

El Khoury, M., Campbell-Sills, H., Salin, F., Guichoux, E., Claisse, O., Lucas, P.M., 2017. Biogeography of Oenococcus oeni Reveals Distinctive but Nonspecific Populations in Wine-Producing Regions. Applied and environmental microbiology 83, e02322–16. https://doi.org/10.1128/AEM.02322-16

Merceron, N.R., Leroy, T., Chancerel, E., Romero-Severson, J., Borkowski, D.S., Ducousso, A., Monty, A., Porté, A.J., Kremer, A., 2017. Back to America: tracking the origin of European introduced populations of Quercus rubra L. Genome 60, 778–790. https://doi.org/10.1139/gen-2016-0187

Meyer-Sand, B.R., Blanc-Jolivet, C., Mader, M., Paredes-Villanueva, K., Tysklind, N., Sebbenn, A.M., Guichoux, E., Degen, B., 2017. Development of a set of SNP markers for population genetics studies of Ipe (Handroanthus sp.), a valuable tree genus from Latin America. Conservation Genetics Resources 1–3. https://doi.org/10.1007/s12686-017-0928-5

Truffaut, L., Chancerel, E., Ducousso, A., Dupouey, J.L., Badeau, V., Ehrenmann, F., Kremer, A., 2017. Fine-scale species distribution changes in a mixed oak stand over two successive generations. New Phytologist 215, 126–139. https://doi.org/10.1111/nph.14561

Wan, Q., Zheng, Z., Huang, K., Guichoux, E., Petit, R.J., 2017. Genetic divergence within the monotypic tree genus Platycarya (Juglandaceae) and its implications for species’ past dynamics in subtropical China. Tree Genetics & Genomes 13, 73. http://dx.doi.org/10.1007/s11295-017-1153-9